Human enhancers associated with immune response harbour specific sequence composition, activity, and genome organization

نویسندگان

  • Charles-Henri Lecellier
  • Wyeth W. Wasserman
  • Remo Rohs
  • Anthony Mathelier
چکیده

23 The FANTOM5 consortium recently characterized 38,554 robust hu24 man enhancers from 808 cell and tissue types using the Cap Analysis of 25 Gene Expression technology. We used the distribution of guanine and 26 cytosine nucleotides at enhancer regions to distinguish two classes of en27 hancers harboring distinct DNA structural properties. A functional anal28 ysis of their predicted gene targets highlighted one class of enhancers as 29 significantly enriched for associations with immune response genes. More30 over, these enhancers were specifically enriched for regulatory motifs rec31 ognized by TFs involved in immune response. We observed that immune 32 response enhancers were cell type specific, preferentially activated upon 33 bacterial infection, and with long-lasting response activity. Looking at 34 chromatin capture data, we found that the two classes of enhancers were 35 lying in distinct topologically-associated domains and chromatin loops. 36 Our results suggest that specific DNA sequence patterns encode for classes 37 of enhancers that are functionally distinct and specifically organized in the 38 human genome. 39

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تاریخ انتشار 2016